Dimethylformamide

Explore Chemical Grades

• #DH3851

  Anhydrosolv Grade N,N-Dimethylformamide (DMF): Ultra-Low Water DMF for Moisture-Sensitive Applications

  Engineered for Consistency, Available in Bulk Tankers, and Trusted by Global Oligo Manufacturers

  • Ultra-Low Water Content <10 ppm

    Support sensitive reactions and process consistency with a high-purity polar aprotic solvent designed for ultra-low water and minimal nonvolatile residue

     

  • High Purity & Reliable Assay

    Manufactured to stringent purity standards, delivering consistent composition and dependable performance in demanding pharmaceutical, analytical, and chemical manufacturing applications

  • Minimal Nonvolatile Residue

    Low residue after evaporation helps reduce the risk of unwanted carryover, contamination, or downstream interference in sensitive processes

  • Ideal for Moisture-Sensitive Synthesis

    A strong choice for reactions where water can impact coupling efficiency, reagent stability, reaction completion, or product quality 
     

  • Rigorous Quality Control

    Every lot is tested to meet strict specifications, helping provide reliable performance and batch-to-batch consistency 

  • Target Industries

    Pharmaceutical & Life Sciences   Research & Process Development Laboratories   Specialty Chemical Manufacturing   High-Performance Polymers & Membranes manufacturing   Advanced Materials Manufacturing 

  • Use cases

    Moisture-Sensitive Organic Synthesis where water control can help protect reaction performance and reproducibility  

    Peptide synthesis workflows where minimizing water supports cleaner coupling conditions and helps reduce the risk of hydrolysis of activated intermediates 

    API Manufacturing where impurity and moisture control are important to process performance 

    Supports route scouting, process optimization, and scale-up activities by providing consistent solvent quality across Pharmaceutical development stages 

    Specialty Chemical Synthesis requiring a highly polar solvent with controlled water and low nonvolatile residue 

    Specialty polymers, coatings, and membranes where solvent purity and water control can influence product quality and performance 

  Technical data sheet (TDS)
• #DS1451

  HPLC Grade N,N-Dimethylformamide (DMF) - High-Purity DMF for Analytical Confidence

  Support accurate separations, stable baselines, and reproducible analytical results with a solvent optimized for HPLC applications

  • Optimized for Analytical Workflows

    Designed for HPLC and spectroscopic applications where solvent purity, low residue, and UV transparency can directly impact data quality and method performance 

  • Low Residue for Cleaner Results

    Minimal residue after evaporation helps reduce background interference and supports cleaner analytical interpretation 

  • Controlled Optical Absorbance

    Tested across key UV wavelengths to support applications where solvent background absorbance can affect sensitivity, baseline stability, or analytical confidence 

  • Consistent Lot-to-Lot Performance

    Strict QC testing helps support reproducible results across methods, runs, and laboratories 

  • High Purity & Low Trace Impurities

    Manufactured under controlled quality standards to help minimize extraneous peaks and improve confidence in chromatographic interpretation 

  • Target Industries

    Pharmaceutical Quality Control   Pharmaceutical R&D   Biotechnology Research   Analytical Testing Laboratories   Academic & Contract Research Laboratories  

     

  • Use Cases

    Bioanalytical and Pharmaceutical Research for compound characterization, comparative studies, and R&D testing 

    Pharmaceutical Quality Control where consistent solvent performance and low background interference is non negotiable 

    Dissolution of APIs, intermediates, reference materials, and difficult-to-solubilize compounds prior to chromatographic analysis 

    Formulation & Preformulation Development, including solubility screening, compatibility testing, and analytical evaluation of drug candidates 

    Analytical methods where purity, UV profile, and reproducibility are important 

     

  Technical data sheet (TDS)
• #DB0455

  Bio Grade N,N-Dimethylformamide (DMF). High-Purity DMF for Peptide Synthesis and Sensitive Biopharma Workflows

  Support SPPS, LPPS, and biomolecular workflows with high-purity DMF tested for amines, water, residue, acid/base content, and optical absorbance

  • Strong Fit for Peptide Synthesis

    DMF is a widely used solvent in peptide synthesis due to its ability to dissolve protected amino acids, peptide fragments, coupling reagents, and deprotection systems while supporting resin swelling in SPPS workflows 

  • Controlled Amines as Dimethylamine

    Bio Grade DMF is tested for amines as dimethylamine, an important impurity to control in Fmoc-based peptide synthesis. Dimethylamine can contribute to unintended Fmoc deprotection, which may increase impurity formation and reduce crude peptide quality 

  • High Purity for Sensitive Workflows

    With high assay, low residue, controlled water, and titratable acid/base specifications, Bio Grade DMF helps reduce solvent-related variability in sensitive synthesis and research applications 

  • Supports Crude Purity and Process Reproducibility

    Bio Grade DMF supports cleaner synthesis conditions, more consistent coupling and deprotection cycles, and improved process confidence 

  • Low UV Background for Analytical Compatibility

    Controlled optical absorbance supports applications where UV background and solvent profile may impact analytical review, in-process testing, or downstream evaluation 

  • Target Industries

    Peptide Synthesis  

    Peptide & Protein Research Laboratories 

    Biotechnology R&D 

    Pharmaceutical Process Development 

     

  • Use Cases

    Solid-Phase Peptide Synthesis (SPPS) 

    Commonly used for resin swelling, amino acid dissolution, coupling reactions, deprotection steps, and wash cycles. High-purity Bio Grade DMF helps maintain a cleaner reaction environment by controlling water, residue, acid/base content, and amines as dimethylamine. 

    Fmoc-Based Peptide Synthesis 

    Bio Grade DMF is especially relevant for Fmoc peptide synthesis because dimethylamine impurities can contribute to premature Fmoc removal. Controlling amine content helps reduce the risk of off-cycle reactions and supports more consistent peptide assembly. 

    Liquid-Phase Peptide Synthesis (LPPS) 

    In LPPS and fragment coupling, DMF can be used to dissolve protected amino acids, peptide fragments, and coupling systems. High-purity solvent quality helps support consistent reaction performance and cleaner downstream purification. 

    Peptide & Biomolecule Research Support 

    Supports synthesis, purification support, and handling of complex biomolecules where solvent purity can influence stability, reproducibility, and analytical confidence. 

    Biopharmaceutical Process Development 

    Provides a high-purity solvent option for early-stage process development, reaction screening, and optimization workflows where impurity control is important. 

    Specialty Biochemical Synthesis 

    Designed for controlled synthesis steps in sensitive biochemical and life-science-related chemical processes. 

  Technical data sheet

• Grade Selection Guide

  Choose Anhydrosolv DMF when:

  Your process is moisture-sensitive and requires ultra-low water content. This grade is best suited for applications where water can impact reaction efficiency, reagent stability, or product quality

  Choose HPLC/Spectro DMF when:

  Your workflow is analytical and requires low residue, high purity, and controlled optical absorbance. This grade is well suited for HPLC, spectroscopic, QC, and sample preparation applications

  Choose Bio Grade DMF when:

  Your application involves peptide synthesis, biomolecular research, or sensitive biopharma workflows where control of amines, acid/base content, residue, water, and UV absorbance can help support cleaner chemistry and reproducible results